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Real members of MyParkinsonsTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

What Are MAO Inhibitors?

A MyParkinsonsTeam Member asked a question đź’­
Reading, PA
August 17
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A MyParkinsonsTeam Member

My husband was on Nardil for years and was not able to take anything else why his neurologist was trying to figure out what was going on with him. First it was PD and now it is PSP. It is the ONLY antidepressant that ever worked for him.

August 17
A MyParkinsonsTeam Member

Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs that are used early in the course of Parkinson’s disease. They work by preventing the breakdown of dopamine in the brain, thereby increasing the amount of dopamine available. MAOIs can be somewhat effective at treating Parkinson’s symptoms and may help Show Full Answer

Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs that are used early in the course of Parkinson’s disease. They work by preventing the breakdown of dopamine in the brain, thereby increasing the amount of dopamine available. MAOIs can be somewhat effective at treating Parkinson’s symptoms and may help protect the brain and slow the progress of the disease. Examples of MAOIs include:

- Azilect (Rasagiline)
- Xadago (Safinamide)
- Selegiline (sold under the brand names Eldepryl and Zelapar)

However, MAOIs can worsen side effects caused by Levodopa. Always consult your doctor for personalized advice.

August 17

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