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Has anyone switched from regular Sinemet (Carbidopa/Levodopa) to Sinemet CR? Are there additional side effects?

It's my first time taking the Sinemet CR100/25 for bedtime.Apparently,it has a longer effectiveness. I will see if it will help me get through the night

I was just talking to someone in the drug section at publix who asked me why i did not take Sinemet instead of Carbidopa, after I had a problem with the new manufacturer they were using for my Carbi. It was not reacting with me well.. I did not know why my doctor did not give me Sinemet. Maybe because the price is higher?? I will have to look into that. My question is, do any of you take Sinemet instead of Carbidopa and why, and if you found it to work better,

My mother who is 81 years has been taking Sinemet for approximately 3 months and is napping 85% during the day when sitting and states that she is tired most of the time. At night sometimes complaints about cramping in feet near toes. Any recommendations??? Are there any exercises that she can do?? She uses a cane and walker.

I have two questions:

1) Is any participating in a clinical trial now or in the past?

2) Is anyone off Sinimet at this time after they started? I'm not taking any other meds either.

I weaned off as per doctor and so far and today is my second day without meds. So far, so good. My pd symptoms are unchanged, and my sleeping is so much better. I'm still dealing with my anxiety and depression, but since weaning off, the last few days seem a little better.

The only thing the Sinimet had… read more

I feel as though I don't get the benefits from the Sinement that I used to. Have only been on Sinement 50/200 CR since August of 2014. I take 1 dose basically every 3 hours from 6am-9pm. I also take Requip 3 times a day. I have tried other things with no success. I do work full-time still. I have lost my balance more as of lately. My tremors are very fine hardly even noticed. Muscle spasms are worse. Meds usually last about 1 1/2 hours… read more

Despite proven effectiveness and wide use of levodopa, usually prescribed as Sinemet® (carbidopa-levodopa), to manage movement symptoms in PD, doubts have lingered over the drug’s long-term safety. Research published Oct 11, 2011 in the journal Neurology, scientists conclude that larger cumulative doses of levodopa, taken for years or decades, do not harm critical brain cells in people with Parkinson’s.

The long-term use of levodopa is associated with dyskinesia and “wearing-off” periods in… read more