Serotonin Syndrome is caused by too much serotonin production b the brain. Carbidopa/levidopa helps patients with dopamine production, but also produces serotonin. Unfortunately many PD patients are also sufferers of depression and anxiety. Both of these symptoms tend to get medicated ... by serotonin-producing medicines: that's now serotonin syndrome....overproduction of serotonin, which comes with its own set of symptoms, like fatigue, confusion, vision problems, weakness and imbalance, and many more. Too much SS and you can become toxic, leading to death. These symptoms are all common complaints of PD patients, tho in may cases, aren't the result of the P Disease, but rather the treatment of complaints with improper medications. My doctors have now taken me off of FIVE medications, have replaced 2 meds, and are having me weaned off another two meds. Part of my problem is DiP - Drug Induced Parkinsonism, just plain too many drugs at one time, with adverse interactions going on between them, causing Parkinsonism.

I’m uncertain what PiD is in reference to your question; for me it’s what I had after complications of childbirth with my first baby. Sooo…and is Serotonin Syndrome associated with Parkinsonism?

This is big pharma at its finest perhaps, but more likely doctors using meds without being certain of what they are treating? Maybe all kinds of reasons. I’ve had a PCP years ago who every year took me off of as many meds as he could with the understanding that I may have to go back on them, but at the very least it gave my body a rest, and time to evaluate whether I still needed them. My neurologist never added more than one medication at a time starting small and increasing gradually. Now I’m in hospice and I take very few meds. The only problem was when they reduced Clonazepam by .5 milligrams and within hours of missing that one dose my tremor was all over the place and I was hallucinating. My BP is too low to give me something to take my lasix , but the extra fluid is causing my heart failure to worsen. I. Many ways I feel better without all the meds, but I am losing ground much faster now, or so it seems, but my point is I no longer have to worry about drug interactions; things will take their natural course.
I don’t think I would do well with the issues it seems you must be fighting; never knowing for sure if it’s meds interacting, a new symptom, a med you don’t tolerate and then what all is affecting your entire system. Practicing medicine is exactly so especially newly licensed doctors. I’ll keep you in my prayers. And your doctor.
Teresa 2