I've been on C/L 25/100 for about 25 yrs. I haven't had that many problems with it. I do get dyskinesia, when I take to much. I'm on two other medicines now since June of this year. Neupro patches is the first one its a 24hr patch the releases a steady stream of medicine. It helps with highs and lows of oral medicine. The second one is Kynmobi sublingual strips this medicine you put under your tongue it help to cut your off time down to 15 to 30 minutes.
Blessings
Susan

My note just disappeared again, how annoying! It was to megMS. Be careful of the MAO inhibitors, they can be dangerous if taken with certain meds. I have been on the Levodopa for a year or so and I get very uncomfortable if I take it late or miss a dose. So you will be tied to it if you start. But you’ll be uncomfortable if you don’t take it too…talk it over with your health team, the pros and cons.