Mirapex ER (Pramipexole) for Parkinson's Disease

The Mirapex ER brand name has been discontinued in the U.S. Generic alternatives may be available.

Overview

Mirapex ER is a prescription drug approved by the U.S. Food and Drug Administration (FDA) in 2010 to treat motor symptoms of Parkinson’s disease. Mirapex ER is also referred to by its drug name, pramipexole. Mirapex ER is not suitable for people with a major psychotic disorder or those who have previously shown hypersensitivity to pramipexole. Mirapex ER must be used with caution in people with high or low blood pressure, asthma, schizophrenia, sleep disorders, heart problems, kidney disease, or a history of alcohol addiction. Mirapex ER may not be appropriate for women who are pregnant or breastfeeding. Mirapex ER is a member of a class of drugs called dopamine agonists. Mirapex ER is believed to work by imitating the action of dopamine in the brain.

How do I take it?

Mirapex ER is taken orally as a tablet once a day. Mirapex ER may be taken with or without food. Taking Mirapex ER with food may help prevent stomach upset. Take Mirapex ER at the same time each day. Do not crush, chew, or split Mirapex ER tablets. Do not drink alcohol while you are taking Mirapex ER. Alcohol can increase the intensity of some side effects. Avoid driving or operating machinery while using Mirapex ER. Do not stop using Mirapex ER suddenly. If you decide to stop using Mirapex ER, form a plan with your doctor for gradually tapering off your dosage to avoid withdrawal symptoms. Always follow your doctor’s instructions exactly when taking Mirapex ER.

Side effects

Common side effects of Mirapex ER include nausea, dizziness, drowsiness, insomnia, constipation, weakness, and hallucinations. Tell your doctor if these side effects become worse. Rarely, dopamine agonists such as Mirapex ER may contribute to the development of melanoma and severe fever. Mirapex ER can also cause users to fall asleep during daily activities or to behave impulsively. Especially in older patients, hallucinations and psychotic behavior may occur. Many drugs can cause allergic reactions and, in the most serious cases, can result in death. Seek immediate medical help if you experience signs of a severe allergic reaction such as hives, difficulty breathing, or swelling in the face, throat, eyes, lips, or tongue.

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Mirapex ER — RxList